TY - JOUR
T1 - Respiratory syncytial virus-associated lower respiratory illnesses
T2 - Possible influence of other agents
AU - Group Health Medical Associates
AU - Ray, C. George
AU - Minnich, Linda L.
AU - Holberg, Catharine J.
AU - Shehab, Ziad M.
AU - Wright, Anne L.
AU - Barton, Leslie L.
AU - Taussig, Lynn M.
AU - Bean, John
AU - Bianchi, Henry
AU - Curtiss, John
AU - Ey, John
AU - Moss, Robert
AU - Rothschild, James
AU - Sanguinetti, Alejandro
AU - Smith, Barbara
AU - Smith, Sandra
AU - West, Neil
AU - Vondrak, Terry
AU - McLellan, Maureen
PY - 1993/1
Y1 - 1993/1
N2 - Acute lower respiratory illnesses were prospectively investigated in a cohort of 1246 healthy infants who were enrolled at birth in the Tucson Children’s Respiratory Study and followed through the first 3 years of life. Respiratory syncytial virus (RSV) infection was documented by culture, antigen detection or both in 276 episodes. In 21 (7.6%) of these 276, other viruses were simultaneously detected. Further serologic studies of 50 episodes in which RSV had been found increased the apparent viral codetection rate to 24%. When culture results for Chlamydia trachomatis and Mycoplasma pneumoniae were also considered, the rate of codetection was found to be 10.9% (30 of 276); this increased to 28% for the subgroup of episodes (14 of 50) that was further studied serologically. Illnesses associated with more than one agent were not significantly different from those involving RSV alone, with respect to month of onset, age at illness, illness type or duration of illness. We conclude that when RSV has been detected in previously healthy infants, routine searches for the concomitant presence of other viruses are usually not warranted.
AB - Acute lower respiratory illnesses were prospectively investigated in a cohort of 1246 healthy infants who were enrolled at birth in the Tucson Children’s Respiratory Study and followed through the first 3 years of life. Respiratory syncytial virus (RSV) infection was documented by culture, antigen detection or both in 276 episodes. In 21 (7.6%) of these 276, other viruses were simultaneously detected. Further serologic studies of 50 episodes in which RSV had been found increased the apparent viral codetection rate to 24%. When culture results for Chlamydia trachomatis and Mycoplasma pneumoniae were also considered, the rate of codetection was found to be 10.9% (30 of 276); this increased to 28% for the subgroup of episodes (14 of 50) that was further studied serologically. Illnesses associated with more than one agent were not significantly different from those involving RSV alone, with respect to month of onset, age at illness, illness type or duration of illness. We conclude that when RSV has been detected in previously healthy infants, routine searches for the concomitant presence of other viruses are usually not warranted.
KW - Coinfections
KW - Lower respiratory tract infections
KW - Respiratory syncytial virus
KW - Respiratory viruses
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U2 - 10.1097/00006454-199301000-00005
DO - 10.1097/00006454-199301000-00005
M3 - Article
C2 - 8417418
AN - SCOPUS:0027475291
SN - 0891-3668
VL - 12
SP - 15
EP - 19
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 1
ER -