Resolution of Chronic Immune Thrombocytopenia Purpura after Autologous Hematopoietic Stem Cell Transplantation for Diffuse Large B-Cell Lymphoma

Prashanth A. Kumar, Ali Wazir, Jeffrey J. Pu

Research output: Contribution to journalArticlepeer-review

Abstract

Immune thrombocytopenic purpura (ITP) is a hematological disorder characterized by immune-mediated destruction of platelets that could be triggered by a number of causes. ITPs are usually treated with steroid, immunomodulators or immunosuppressors, and intravenous immunoglobulin therapy though refractory/relapsed status frequently occurs. It was suggested that autologous hematopoietic stem cell transplant (HSCT) after high-dose chemotherapy conditioning might improve ITP patients’ peripheral blood platelet counts via reorganizing disrupted immune balance in the hematopoietic and hematologic systems. In this case report, we describe how a patient, who suffered from both severe thrombocytopenia due to chronic ITP and refractory/relapsed diffuse large B-cell lymphoma (DLBCL), was managed to successfully receive autologous HSCT using carmustine, etoposide, cytarabine and melphalan (BEAM) conditioning regimens and how his chronic ITP was eventually cured after receiving autologous HSCT. This is the first clinical case in the world demonstrating that high-dose BEAM chemotherapy conditioned autologous HSCT could cure chronic ITP while successfully managing refractory/relapse DLBCL.

Original languageEnglish (US)
Pages (from-to)37-40
Number of pages4
JournalJournal of Medical Cases
Volume12
Issue number1
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • BEAM conditioning regimens
  • Diffuse large B-cell lymphoma
  • Hematopoietic stem cell transplantation
  • Immune thrombocytopenic purpura

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Resolution of Chronic Immune Thrombocytopenia Purpura after Autologous Hematopoietic Stem Cell Transplantation for Diffuse Large B-Cell Lymphoma'. Together they form a unique fingerprint.

Cite this