Requirement of type III TGF-β receptor for endocardial cell transformation in the heart

Christopher B. Brown; Angelique S. Boyer; Raymond B. Runyan; Joey V. Barnett

doi:10.1126/science.283.5410.2080

Requirement of type III TGF-β receptor for endocardial cell transformation in the heart

Christopher B. Brown
, Angelique S. Boyer
, Raymond B. Runyan
, Joey V. Barnett

Cellular and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

346 Scopus citations

Abstract

Transforming growth factor-β (TGF-β) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no dearly defined role in TGF-β signaling. Cardiac endothelial cells that undergo epithelial- mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial ceils conferred transformation in response to TGF-β2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-β signaling.

Original language	English (US)
Pages (from-to)	2080-2082
Number of pages	3
Journal	Science
Volume	283
Issue number	5410
DOIs	https://doi.org/10.1126/science.283.5410.2080
State	Published - Mar 26 1999

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title = "Requirement of type III TGF-β receptor for endocardial cell transformation in the heart",

abstract = "Transforming growth factor-β (TGF-β) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no dearly defined role in TGF-β signaling. Cardiac endothelial cells that undergo epithelial- mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial ceils conferred transformation in response to TGF-β2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-β signaling.",

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year = "1999",

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T1 - Requirement of type III TGF-β receptor for endocardial cell transformation in the heart

AU - Brown, Christopher B.

AU - Boyer, Angelique S.

AU - Runyan, Raymond B.

AU - Barnett, Joey V.

PY - 1999/3/26

Y1 - 1999/3/26

N2 - Transforming growth factor-β (TGF-β) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no dearly defined role in TGF-β signaling. Cardiac endothelial cells that undergo epithelial- mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial ceils conferred transformation in response to TGF-β2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-β signaling.

AB - Transforming growth factor-β (TGF-β) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no dearly defined role in TGF-β signaling. Cardiac endothelial cells that undergo epithelial- mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial ceils conferred transformation in response to TGF-β2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-β signaling.

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Requirement of type III TGF-β receptor for endocardial cell transformation in the heart

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