Reproducibility of trial-based functional MRI on motor imagery

Seung Schik Yoo, Heather M. O'Leary, Jong Hwan Lee, Nan Kuei Chen, Lawrence P. Panych, Ferenc A. Jolesz

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The investigation of the reproducibility in functional MRI (fMRI) is an important step in the quantification and analysis of paradigm-related brain activation. This article reports on reproducibility of cortical activation characterized by repeated fMRI runs (10 times) during the performance of a motor imagery and a passive auditory stimulation as a control task. Two parameters, the size of activation and BOLD signal contrast, were measured from regions-of-interest for 10 subjects across different threshold conditions. The variability of these parameters was normalized with respect to the mean obtained from 10 runs, and represented as the intrasession variability. It was found that the variability was significantly lower in the measurement of BOLD signal contrast as compared to the measurement of the size of activation. The variability of the activation volume measurement was greater in the motor imagery task than in the auditory tasks across all thresholds. This task-dependent difference was not apparent from the measurement of the BOLD signal contrast. The presence of threshold dependence in the variability measurement was also examined, but no such dependency was found. The results suggest that a measurement of BOLD signal itself is a more reliable indicator of paradigm-related brain activation during repeated fMRI scans.

Original languageEnglish (US)
Pages (from-to)215-227
Number of pages13
JournalInternational Journal of Neuroscience
Issue number2
StatePublished - Feb 2007
Externally publishedYes


  • Brain mapping
  • Brain-computer interface
  • Event
  • Evoked potential
  • Neuro-feedback

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Reproducibility of trial-based functional MRI on motor imagery'. Together they form a unique fingerprint.

Cite this