TY - JOUR
T1 - Replication of loci influencing ages at menarche and menopause in Hispanic women
T2 - The Women's Health initiative SHARe study
AU - Chen, Christina T.L.
AU - Fernández-Rhodes, Lindsay
AU - Brzyski, Robert G.
AU - Carlson, Christopher S.
AU - Chen, Zhao
AU - Heiss, Gerardo
AU - North, Kari E.
AU - Woods, Nancy F.
AU - Rajkovic, Aleksandar
AU - Kooperberg, Charles
AU - Franceschini, Nora
N1 - Funding Information:
This work was supported by the Ruth L. Kirschstein National Research Service Award (5T32HL007055 to L.F.-R.); and the American Heart Association (0675001N, 1R01HL089651-01, 1U01HG004803-01 to N.F.). The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32 and 44221.
PY - 2012/3
Y1 - 2012/3
N2 - Several genome-wide studies have identified loci associated with reproductive traits, such as ages of menarche and menopause, in women of European ancestry. In this study, we investigated the relevance of these loci in minority US Hispanic women. We utilized data from 3468 women who were genotyped as a part of the Women's Health Initiative SNP Health Association Resource. We replicated associations of eight loci (LRP18, LIN28B, CENPW, INHBA, TMEM38B, ZNF483, NFAT5 and OLFM2) with age at menarche, and of two loci (MCM8 and BRSK1/TMEM150B) with age at menopause. The MCM8 locus was also associated with early menopause risk. Three loci (CENPW, MCM8 and BRSK1/TMEM150B) were associated with the length of reproductive lifespan. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in minority US Hispanic women.
AB - Several genome-wide studies have identified loci associated with reproductive traits, such as ages of menarche and menopause, in women of European ancestry. In this study, we investigated the relevance of these loci in minority US Hispanic women. We utilized data from 3468 women who were genotyped as a part of the Women's Health Initiative SNP Health Association Resource. We replicated associations of eight loci (LRP18, LIN28B, CENPW, INHBA, TMEM38B, ZNF483, NFAT5 and OLFM2) with age at menarche, and of two loci (MCM8 and BRSK1/TMEM150B) with age at menopause. The MCM8 locus was also associated with early menopause risk. Three loci (CENPW, MCM8 and BRSK1/TMEM150B) were associated with the length of reproductive lifespan. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in minority US Hispanic women.
UR - http://www.scopus.com/inward/record.url?scp=84863231584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863231584&partnerID=8YFLogxK
U2 - 10.1093/hmg/ddr570
DO - 10.1093/hmg/ddr570
M3 - Article
C2 - 22131368
AN - SCOPUS:84863231584
SN - 0964-6906
VL - 21
SP - 1419
EP - 1432
JO - Human molecular genetics
JF - Human molecular genetics
IS - 6
M1 - ddr570
ER -