@article{5f24f8c83970447092919ba3567020ff,
title = "Repair and remodeling of partial-weightbearing, uninstrumented long bone fracture model in mice treated with low intensity vibration therapy",
abstract = "Background: While vibration therapy has shown encouraging results across many fields of medicine in the last decade, its role as originally envisioned for bone health remains uncertain. Especially regarding its efficacy in promoting fracture healing, mixed and incomplete outcomes suggest a need to clarify its potential. In particular, the definitive effect of vibration, when isolated from the confounding mechanical inputs of gait and stabilizing instrumentation, remains largely unknown. Methods: Four cohorts of C57BL/6 male mice underwent single-leg, open fibula fracture. Vibration was applied at 0.3 g to two groups for 20 min/d. At 3 and 6 weeks, fibulae were harvested for microcomputed tomography and 3-point bending to failure. Findings: In bone volume and tissue volume, the groups at each healing time point were statistically not different. At 3 weeks, however, the ratio of bone-to-tissue volume was lower for the vibrated group than control. Likewise, while bone mineral density did not differ, tissue volume density was lowest with vibration. At 6 weeks, mean differences were nominal. Biomechanically, vibration consistently trended ahead of control in strength and stiffness, but did not achieve statistical significance. Interpretation: At this stage of therapeutic development, vibration therapy in isolation does not demonstrate a clear efficacy for bone healing, although further treatment permutations and translational uses remain open for investigation.",
keywords = "Bone density, Low-magnitude, Stiffness, Strength, Therapy, Vibration, Whole-body",
author = "Wenger, {Karl H.} and Diana Heringer and Tammilee Lloyd and Johnson, {Maria S.} and DesJardins, {John D.} and Stanley, {Scott E.} and Bethany Remeniuk and Szivek, {John A.}",
note = "Funding Information: The authors wish to thank the following contributors, who all provided excellent services to the study:, 1) At the University of Arizona: University Animal Care personnel, for protocol consultation, oversight of animal care, and provision of surgical facilities; Department of Mechanical Engineering, for fabrication of biomechanical apparatus; Department of Pharmacology, for Faxitron scanning resources, Frank Porecca, Ph.D. lab director; and Jacalyn Ouellette, M.S. Department of Biomedical Engineering, for qualification of vibration platform. Additional animal support was provided by Monika Keith, Augusta, Georgia. 2) Small Animal Phenotyping Core, University of Alabama at Birmingham, for μCT scanning resources, Tim R. Nagy, Ph.D. director, Xuemei Cao, additional technical consultation; supported by the UAB Nutrition Obesity Research Center (National Institutes of Health USA P30DK056336), UAB Diabetes Research Center (NIH P30DK079626) and UAB Nathan Shock Center (NIH P30AG050886A). 3) Lab Equipment Services, Medical College of Georgia, Augusta University, Greg White, fabricator, for design consultation, machining, and construction of vibration platform. 4) Carol Evans, Regencor Foundation, Inc. for grant management, and Dr. Richard Sebastian, for surgery model development. Funding Information: This study was graciously funded by the AO Foundation, Davos, Switzerland (S-12-83 W). Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2021",
month = jan,
doi = "10.1016/j.clinbiomech.2020.105244",
language = "English (US)",
volume = "81",
journal = "Clinical Biomechanics",
issn = "0268-0033",
publisher = "Elsevier Limited",
}