TY - JOUR
T1 - Remaking memories
T2 - Reconsolidation updates positively motivated spatial memory in rats
AU - Jones, Bethany
AU - Bukoski, Elizabeth
AU - Nadel, Lynn
AU - Fellous, Jean Marc
N1 - Funding Information:
1Research reported in this article was supported by Cooperative Agreement 3-UO1-HS08578 from the Agency for Health Care Policy and Research and by Grant 5-P50-MH45294 from the National Institute of Mental Health. The views expressed in the article are those of the authors, and no official endorsement by the Department of Health and Human Services or by the Agency for Health Care Policy and Research should be inferred. We thank Carl Maida and Julie Brown for their valuable assistance in data collection. 2To Whom correspondence should be addressed at Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 2101 East Jefferson Street, Rockville, Maryland 20852.
PY - 2012/3
Y1 - 2012/3
N2 - There is strong evidence that reactivation of a memory returns it to a labile state, initiating a restabilization process termed reconsolidation, which allows for updating of the memory. In this study we investigated reactivation-dependent updating using a new positively motivated spatial task in rodents that was designed specifically to model a human list-learning paradigm. On Day 1, rats were trained to run to three feeders (List 1) for rewards. On Day 2, rats were trained to run to three different feeders (List 2) in either the same (Reminder condition) or a different (No Reminder condition) experimental context than on Day 1. On Day 3, rats were cued to recall List 1. Rats in the Reminder condition made significantly more visits to List 2 feeders (intrusions) during List 1 recall than rats in the No Reminder condition, indicating that the reminder triggered reactivation and allowed integration of List 2 items into List 1. This reminder effect was selective for the reactivated List 1 memory, as no intrusions occurred when List 2 was recalled on Day 3. No intrusions occurred when retrieval took place in a different context from the one used at encoding, indicating that the expression of the updated memory is dependent upon the retrieval context. Finally, the level of intrusions was highest when retrieval took place immediately after List 2 learning, and generally declined when retrieval occurred 1-4 h later, indicating that the List 2 memory competed with short-term retrieval of List 1. These results demonstrate the dynamic nature of memory over time and the impact of environmental context at different stages of memory processing.
AB - There is strong evidence that reactivation of a memory returns it to a labile state, initiating a restabilization process termed reconsolidation, which allows for updating of the memory. In this study we investigated reactivation-dependent updating using a new positively motivated spatial task in rodents that was designed specifically to model a human list-learning paradigm. On Day 1, rats were trained to run to three feeders (List 1) for rewards. On Day 2, rats were trained to run to three different feeders (List 2) in either the same (Reminder condition) or a different (No Reminder condition) experimental context than on Day 1. On Day 3, rats were cued to recall List 1. Rats in the Reminder condition made significantly more visits to List 2 feeders (intrusions) during List 1 recall than rats in the No Reminder condition, indicating that the reminder triggered reactivation and allowed integration of List 2 items into List 1. This reminder effect was selective for the reactivated List 1 memory, as no intrusions occurred when List 2 was recalled on Day 3. No intrusions occurred when retrieval took place in a different context from the one used at encoding, indicating that the expression of the updated memory is dependent upon the retrieval context. Finally, the level of intrusions was highest when retrieval took place immediately after List 2 learning, and generally declined when retrieval occurred 1-4 h later, indicating that the List 2 memory competed with short-term retrieval of List 1. These results demonstrate the dynamic nature of memory over time and the impact of environmental context at different stages of memory processing.
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U2 - 10.1101/lm.023408.111
DO - 10.1101/lm.023408.111
M3 - Article
C2 - 22345494
AN - SCOPUS:84858590051
SN - 1072-0502
VL - 19
SP - 91
EP - 98
JO - Learning and Memory
JF - Learning and Memory
IS - 3
ER -