Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis

Greg Gilles, Arjun Vohra, Dagoberto Robles, Mihra S. Taljanovic, Erin L. Ashbeck, Chelsea Caruso, Jeffrey Duryea, Edward J. Bedrick, Ali Guermazi, C. Kent Kwoh

Research output: Contribution to journalArticlepeer-review

Abstract

Effusion-synovitis (ES) is recognized as a component of osteoarthritis, creating a need for rapid methods to assess ES on MRI. We describe the development and reliability of an efficient single-slice semi-automated quantitative approach to measure ES. We used two samples from the Osteoarthritis Initiative (OAI): 50 randomly selected OAI participants with radiographic osteoarthritis (i.e., Kellgren–Lawrence (KL) grade 2 or 3) and a subset from the Foundation for the National Institutes of Health Osteoarthritis Biomarker study. An experienced musculoskeletal radiologist trained four non-expert readers to use custom semi-automated software to measure ES on a single axial slice and then read scans blinded to prior assessments. The estimated intraclass correlation coefficient (ICC) for intra-reader reliability of the single-slice ES method in the KL 2–3 sample was 0.96 (95% CI: 0.93, 0.97), and for inter-reader reliability, the ICC was 0.90 (95% CI: 0.87, 0.95). The intra-reader mean absolute difference (MAD) was 35 mm3 (95% CI: 28, 44), and the inter-reader MAD was 61 mm3 (95% CI: 48, 76). Our single-slice quantitative knee ES measurement offers a reliable, valid, and efficient surrogate for multi-slice quantitative and semi-quantitative assessment.

Original languageEnglish (US)
Article number2691
JournalJournal of Clinical Medicine
Volume12
Issue number7
DOIs
StatePublished - Apr 2023

Keywords

  • MRI
  • biomarkers
  • effusion
  • inflammation
  • knee
  • osteoarthritis
  • quantitative imaging
  • semi-automated
  • synovitis

ASJC Scopus subject areas

  • General Medicine

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