Relative conformational rigidity in oxytocin and [1 penicillamine] oxytocin. A proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism

J. P. Meraldi; V. J. Hruby; A. I.R. Brewster

doi:10.1073/pnas.74.4.1373

Relative conformational rigidity in oxytocin and [1 penicillamine] oxytocin. A proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism

J. P. Meraldi, V. J. Hruby, A. I.R. Brewster

Research output: Contribution to journal › Article › peer-review

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Abstract

A comparative study of the proton and carbon 13 nuclear magnetic resonance spectral parameters of the peptide hormone oxytocin and of its competitive inhibitor [1 L penicillamine]oxytocin has been made, and the results analyzed in terms of comparative conformational and dynamic properties. The results indicate that oxytocin has a flexible conformation, while [1 L penicillamine]oxytocin has a more restricted conformation. The results provide a framework for understanding the mechanism of peptide hormone agonism and antagonism for these compounds, and an approach for understanding some features of the interaction of the hormone and related compounds with their receptor.

Original language	English (US)
Pages (from-to)	1373-1377
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	74
Issue number	4
DOIs	https://doi.org/10.1073/pnas.74.4.1373
State	Published - 1977
Externally published	Yes

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Meraldi, J. P., Hruby, V. J., & Brewster, A. I. R. (1977). Relative conformational rigidity in oxytocin and [1 penicillamine] oxytocin. A proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism. Proceedings of the National Academy of Sciences of the United States of America, 74(4), 1373-1377. https://doi.org/10.1073/pnas.74.4.1373

Relative conformational rigidity in oxytocin and [1 penicillamine] oxytocin. A proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism. / Meraldi, J. P.; Hruby, V. J.; Brewster, A. I.R.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 74, No. 4, 1977, p. 1373-1377.

Research output: Contribution to journal › Article › peer-review

Meraldi, JP, Hruby, VJ & Brewster, AIR 1977, 'Relative conformational rigidity in oxytocin and [1 penicillamine] oxytocin. A proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism', Proceedings of the National Academy of Sciences of the United States of America, vol. 74, no. 4, pp. 1373-1377. https://doi.org/10.1073/pnas.74.4.1373

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Relative conformational rigidity in oxytocin and [1 penicillamine] oxytocin. A proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism

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