Relationships between aqueous solubility and octanol-water partition coefficients

D. Mackay, A. Bobra, W. Y. Shiu, S. H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

207 Scopus citations


The physical chemical equations relating solubility to octanol water partition coefficient are presented and used to develop a new correlation between these quantities which includes a melting point (fugacity ratio) correction. The correlation is satisfactory for 45 organic compounds but it is not applicable to organic acids. When applied to very high molecular weight (> 290) compounds the correlation is less satisfactory; either it is believed because the data are inaccurate or because the tendency for these compounds to partition into organic phases is less than expected. This may have profound environmental implications.

Original languageEnglish (US)
Pages (from-to)701-711
Number of pages11
Issue number11
StatePublished - 1980

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Relationships between aqueous solubility and octanol-water partition coefficients'. Together they form a unique fingerprint.

Cite this