TY - JOUR
T1 - Relationship of parental smoking to wheezing and nonwheezing lower respiratory tract illnesses in infancy
AU - Wright, Anne L.
AU - Holberg, Catharine
AU - Martinez, Fernando D.
AU - Taussig, Lynn M.
N1 - Funding Information:
Exposure of children to passive cigarette smoke has been linked to a variety of respiratory problems, including wheezing and other respiratory symptoms during the first year of life 1-4 and the occurrence of lower respiratory tract Supported by a Specialized Center of Research Grant (No. 14136) from the National Heart, Lung, and Blood Institute. Submitted for publication Jan. 9, 1990; accepted Sept. 11, 1990. Reprint requests: Anne Wright, PhD, Department of Pediatrics, Arizona Health Sciences Center, Tucson, AZ 85724. *The Group Health Medical Associates staff includes John Bean, MD, Henry Bianchi, MD, John Curtiss, MD, John Ey, MD, Robert Moss, MD, James Rothschild, MD, Alejandro Sauguineti, MD, Barbara Smith, MD, Neff West, MD, Terry Vondrak, MD, and Maureen McLellen, RN, PNP. 9/20/25389 illness. 51~ Children whose parents smoke have also been found to differ in lung function, 2, 11-12 in the severity of respiratory illness as measured by rates of hospitaliza-
PY - 1991/2
Y1 - 1991/2
N2 - The relationship between parental smoking and lower respiratory tract illness (LRI) was studied in a large cohort of infants followed prospectively from birth. illnesses were diagnosed by physicians using agreed-on criteria, and parental smoking histories were obtained by questionnaire. The LRIs were differentiated into wheezing and nonwheezing episodes, and the age at first illness of either type was evaluated in relation to smoking by parents. The odds of having an LRI were significantly higher in children whose mothers smoked (odds ratio 1.52; confidence interval 1.07 to 2.15). The odds were higher if the mother smoked a pack of cigarettes or more per day and if the child stayed home rather than attending day care (odds ratio 2.8; confidence interval 1.43 to 5.5). Logistic regression indicated that the LRI rate was significantly elevated both in children exposed to heavy maternal smoke in the absence of day care, and in those who use day care but were not exposed to maternal smoking of a pack or more per day. These findings could nor be attributed to other confounding variables. Nelther paternal smoking nor smoking by other household members was consistently related to the LRI rate. The relationship of maternal smoking to LRI rate was evident for both wheezing and nonwheezing illnesses. Maternal smoking of a pack or more per day was also related to an early age at first LRI, for both wheezing (p<0.05) and nonwheezing (p<0.002) illnesses. In sum, maternal smoking is associated with a higher rate of LRIs in the first year, particularly when mothers smoked a pack or more per day and when the child did not use day care.
AB - The relationship between parental smoking and lower respiratory tract illness (LRI) was studied in a large cohort of infants followed prospectively from birth. illnesses were diagnosed by physicians using agreed-on criteria, and parental smoking histories were obtained by questionnaire. The LRIs were differentiated into wheezing and nonwheezing episodes, and the age at first illness of either type was evaluated in relation to smoking by parents. The odds of having an LRI were significantly higher in children whose mothers smoked (odds ratio 1.52; confidence interval 1.07 to 2.15). The odds were higher if the mother smoked a pack of cigarettes or more per day and if the child stayed home rather than attending day care (odds ratio 2.8; confidence interval 1.43 to 5.5). Logistic regression indicated that the LRI rate was significantly elevated both in children exposed to heavy maternal smoke in the absence of day care, and in those who use day care but were not exposed to maternal smoking of a pack or more per day. These findings could nor be attributed to other confounding variables. Nelther paternal smoking nor smoking by other household members was consistently related to the LRI rate. The relationship of maternal smoking to LRI rate was evident for both wheezing and nonwheezing illnesses. Maternal smoking of a pack or more per day was also related to an early age at first LRI, for both wheezing (p<0.05) and nonwheezing (p<0.002) illnesses. In sum, maternal smoking is associated with a higher rate of LRIs in the first year, particularly when mothers smoked a pack or more per day and when the child did not use day care.
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U2 - 10.1016/S0022-3476(05)80484-6
DO - 10.1016/S0022-3476(05)80484-6
M3 - Article
C2 - 1993946
AN - SCOPUS:0026015949
SN - 0022-3476
VL - 118
SP - 207
EP - 214
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 2
ER -