Relationship of meeting physical activity guidelines with health-related utility

Kai Sun, Jing Song, Jungwha Lee, Rowland W. Chang, Charles B. Eaton, Linda Ehrlich-Jones, Kent C. Kwoh, Larry M. Manheim, Pamela A. Semanik, Leena Sharma, Min Woong Sohn, Dorothy D. Dunlop

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objective Health-related utility measures overall health status and quality of life and is commonly incorporated into cost-effectiveness analyses. This study investigates whether attainment of federal physical activity guidelines translates into better health-related utility in adults with or at risk for knee osteoarthritis (OA). Methods Cross-sectional data from 1,908 adults with or at risk for knee OA participating in the accelerometer ancillary study of the Osteoarthritis Initiative were assessed. Physical activity was measured using 7 days of accelerometer monitoring and was classified as 1) meeting guidelines (≥150 bouted moderate-to-vigorous [MV] minutes per week); 2) insufficiently active (≥1 MV bout[s] per week but below guidelines); or 3) inactive (zero MV bouts per week). A Short Form 6D health-related utility score was derived from patient-reported health status. Relationship of physical activity levels to median health-related utility adjusted for socioeconomic and health factors was tested using quantile regression. Results Only 13% of participants met physical activity guidelines, and 45% were inactive. Relative to the inactive group, median health-related utility scores were significantly greater for the meeting guidelines group (0.063; 95% confidence interval [95% CI] 0.055, 0.071) and the insufficiently active group (0.059; 95% CI 0.054, 0.064). These differences showed a statistically significant linear trend and strong cross-sectional relationship with physical activity level even after adjusting for socioeconomic and health factors. Conclusion We found a significant positive relationship between physical activity level and health-related utility. Interventions that encourage adults, including persons with knee OA, to increase physical activity even if recommended levels are not attained may improve their quality of life.

Original languageEnglish (US)
Pages (from-to)1041-1047
Number of pages7
JournalArthritis Care and Research
Issue number7
StatePublished - Jul 2014

ASJC Scopus subject areas

  • Rheumatology


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