Abstract
The molar solubilization capacities (κ) and the molar micelle-water partition coefficients (K(M)(N)) in Polysorbate 80 of several drugs (including barbiturates, steroids, and benzoic acid derivatives) are related to their log octanol-water partition coefficients (logP). Both κ and K(M)(N) values were calculated from solubility versus Polysorbate 80 concentration profiles, which were either experimentally determined or obtained from the literature. There is a linear relationship between logP of the tested compounds and the logarithm of the molar micelle-water partition coefficient (logK(M)(N)). On the other hand molar solubilization capacities are nearly independent of logP. It is shown that the ability of Polysorbate 80 to solubilize a drug can be predicted from its logP value. Copyright (C) 2000 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 217-222 |
Number of pages | 6 |
Journal | International Journal of Pharmaceutics |
Volume | 200 |
Issue number | 2 |
DOIs | |
State | Published - May 10 2000 |
Keywords
- Octanol-water
- Partition coefficients
- Polysorbate 80
- Solubilization descriptors
ASJC Scopus subject areas
- Pharmaceutical Science