Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

Austin G. Hester; Robert C. Murphy; Charis J. Uhlson; Priscilla Ivester; Tammy C. Lee; Susan Sergeant; Leslie R. Miller; Timothy D. Howard; Rasika A. Mathias; Floyd H. Chilton

doi:10.1074/jbc.M114.579557

Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

Austin G. Hester
, Robert C. Murphy
, Charis J. Uhlson
, Priscilla Ivester
, Tammy C. Lee
, Susan Sergeant
, Leslie R. Miller
, Timothy D. Howard
, Rasika A. Mathias
, Floyd H. Chilton

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.

Original language	English (US)
Pages (from-to)	22482-22489
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.579557
State	Published - Aug 8 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.579557

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@article{f95d8eafb3964cc5bb6c70aaf7de2a39,

title = "Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans",

abstract = "Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.",

author = "Hester, \{Austin G.\} and Murphy, \{Robert C.\} and Uhlson, \{Charis J.\} and Priscilla Ivester and Lee, \{Tammy C.\} and Susan Sergeant and Miller, \{Leslie R.\} and Howard, \{Timothy D.\} and Mathias, \{Rasika A.\} and Chilton, \{Floyd H.\}",

year = "2014",

month = aug,

day = "8",

doi = "10.1074/jbc.M114.579557",

language = "English (US)",

volume = "289",

pages = "22482--22489",

journal = "Journal of Biological Chemistry",

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publisher = "American Society for Biochemistry and Molecular Biology Inc.",

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TY - JOUR

T1 - Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

AU - Hester, Austin G.

AU - Murphy, Robert C.

AU - Uhlson, Charis J.

AU - Ivester, Priscilla

AU - Lee, Tammy C.

AU - Sergeant, Susan

AU - Miller, Leslie R.

AU - Howard, Timothy D.

AU - Mathias, Rasika A.

AU - Chilton, Floyd H.

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.

AB - Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.

UR - https://www.scopus.com/pages/publications/84905833501

UR - https://www.scopus.com/pages/publications/84905833501#tab=citedBy

U2 - 10.1074/jbc.M114.579557

DO - 10.1074/jbc.M114.579557

M3 - Article

C2 - 24962583

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SN - 0021-9258

VL - 289

SP - 22482

EP - 22489

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 32

ER -

Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

Abstract

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