Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

Austin G. Hester; Robert C. Murphy; Charis J. Uhlson; Priscilla Ivester; Tammy C. Lee; Susan Sergeant; Leslie R. Miller; Timothy D. Howard; Rasika A. Mathias; Floyd H. Chilton

doi:10.1074/jbc.M114.579557

Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

Austin G. Hester, Robert C. Murphy, Charis J. Uhlson, Priscilla Ivester, Tammy C. Lee, Susan Sergeant, Leslie R. Miller, Timothy D. Howard, Rasika A. Mathias, Floyd H. Chilton

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.

Original language	English (US)
Pages (from-to)	22482-22489
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.579557
State	Published - Aug 8 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans",

abstract = "Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.",

author = "Hester, {Austin G.} and Murphy, {Robert C.} and Uhlson, {Charis J.} and Priscilla Ivester and Lee, {Tammy C.} and Susan Sergeant and Miller, {Leslie R.} and Howard, {Timothy D.} and Mathias, {Rasika A.} and Chilton, {Floyd H.}",

year = "2014",

month = aug,

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doi = "10.1074/jbc.M114.579557",

language = "English (US)",

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T1 - Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

AU - Hester, Austin G.

AU - Murphy, Robert C.

AU - Uhlson, Charis J.

AU - Ivester, Priscilla

AU - Lee, Tammy C.

AU - Sergeant, Susan

AU - Miller, Leslie R.

AU - Howard, Timothy D.

AU - Mathias, Rasika A.

AU - Chilton, Floyd H.

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.

AB - Background: Genetic variants in the FADS cluster are determinants of arachidonate synthesis, but their role in eicosanoid generation remains unclear. Results: FADS SNP, rs174537 is associated with leukotriene B4 and 5-HETE production from stimulated human blood. Conclusion: A FADS SNP affects the synthesis of 5-lipoxygenase products. Significance: FADS variation may influence inflammation via eicosanoid biosynthesis.

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Relationship between a common variant in the fatty acid desaturase (FADS) clusterand eicosanoid generation in humans

Abstract

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