Relation of age and apolipoprotein E to cognitive function in Down syndrome adults

Gene E. Alexander; Ann M. Saunders; Joanna Szczepanik; Terri L. Strassburger; Pietro Pietrini; Alessio Dani; Maura L. Furey; Marc J. Mentis; Allen D. Roses; Stanley I. Rapoport; Mark B. Schapiro

doi:10.1097/00001756-199705260-00009

Relation of age and apolipoprotein E to cognitive function in Down syndrome adults

Gene E. Alexander, Ann M. Saunders, Joanna Szczepanik, Terri L. Strassburger, Pietro Pietrini, Alessio Dani, Maura L. Furey, Marc J. Mentis, Allen D. Roses, Stanley I. Rapoport, Mark B. Schapiro

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

TO test the cognitive effects of aging and apolipoprotein E (APOE) in individuals at high risk for Alzheimer's disease (AD), we assessed APOE genotypes and performance on a battery of neuropsychological tests in 41 non- demented, Down syndrome (DS) adults. Old DS subjects (ages 41-61 years) showed poorer memory and orientation scores than young DS adults (ages 22-38 years), but the groups did not differ in other measures after we controlled for intellectual function. Language ability was inversely related to APOE genotype, even after age was controlled for, with the presence of the ε2 allele corresponding to better language skills than ε4. Age-related cognitive changes in non-demented DS adults are consistent with the early effects of AD. The relationship between basic linguistic skills and APOE genotype supports this genetic factor in influencing the development of dementia and AD neuropathology in DS.

Original language	English (US)
Pages (from-to)	1835-1840
Number of pages	6
Journal	NeuroReport
Volume	8
Issue number	8
DOIs	https://doi.org/10.1097/00001756-199705260-00009
State	Published - 1997
Externally published	Yes

Keywords

Aging
Alzheimer's disease
Apolipoprotein E
Cognition
Down syndrome
Neuropsychology

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-199705260-00009

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title = "Relation of age and apolipoprotein E to cognitive function in Down syndrome adults",

abstract = "TO test the cognitive effects of aging and apolipoprotein E (APOE) in individuals at high risk for Alzheimer's disease (AD), we assessed APOE genotypes and performance on a battery of neuropsychological tests in 41 non- demented, Down syndrome (DS) adults. Old DS subjects (ages 41-61 years) showed poorer memory and orientation scores than young DS adults (ages 22-38 years), but the groups did not differ in other measures after we controlled for intellectual function. Language ability was inversely related to APOE genotype, even after age was controlled for, with the presence of the ε2 allele corresponding to better language skills than ε4. Age-related cognitive changes in non-demented DS adults are consistent with the early effects of AD. The relationship between basic linguistic skills and APOE genotype supports this genetic factor in influencing the development of dementia and AD neuropathology in DS.",

keywords = "Aging, Alzheimer's disease, Apolipoprotein E, Cognition, Down syndrome, Neuropsychology",

author = "Alexander, {Gene E.} and Saunders, {Ann M.} and Joanna Szczepanik and Strassburger, {Terri L.} and Pietro Pietrini and Alessio Dani and Furey, {Maura L.} and Mentis, {Marc J.} and Roses, {Allen D.} and Rapoport, {Stanley I.} and Schapiro, {Mark B.}",

year = "1997",

doi = "10.1097/00001756-199705260-00009",

language = "English (US)",

volume = "8",

pages = "1835--1840",

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AU - Alexander, Gene E.

AU - Saunders, Ann M.

AU - Szczepanik, Joanna

AU - Strassburger, Terri L.

AU - Pietrini, Pietro

AU - Dani, Alessio

AU - Furey, Maura L.

AU - Mentis, Marc J.

AU - Roses, Allen D.

AU - Rapoport, Stanley I.

AU - Schapiro, Mark B.

PY - 1997

Y1 - 1997

N2 - TO test the cognitive effects of aging and apolipoprotein E (APOE) in individuals at high risk for Alzheimer's disease (AD), we assessed APOE genotypes and performance on a battery of neuropsychological tests in 41 non- demented, Down syndrome (DS) adults. Old DS subjects (ages 41-61 years) showed poorer memory and orientation scores than young DS adults (ages 22-38 years), but the groups did not differ in other measures after we controlled for intellectual function. Language ability was inversely related to APOE genotype, even after age was controlled for, with the presence of the ε2 allele corresponding to better language skills than ε4. Age-related cognitive changes in non-demented DS adults are consistent with the early effects of AD. The relationship between basic linguistic skills and APOE genotype supports this genetic factor in influencing the development of dementia and AD neuropathology in DS.

AB - TO test the cognitive effects of aging and apolipoprotein E (APOE) in individuals at high risk for Alzheimer's disease (AD), we assessed APOE genotypes and performance on a battery of neuropsychological tests in 41 non- demented, Down syndrome (DS) adults. Old DS subjects (ages 41-61 years) showed poorer memory and orientation scores than young DS adults (ages 22-38 years), but the groups did not differ in other measures after we controlled for intellectual function. Language ability was inversely related to APOE genotype, even after age was controlled for, with the presence of the ε2 allele corresponding to better language skills than ε4. Age-related cognitive changes in non-demented DS adults are consistent with the early effects of AD. The relationship between basic linguistic skills and APOE genotype supports this genetic factor in influencing the development of dementia and AD neuropathology in DS.

KW - Aging

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Cognition

KW - Down syndrome

KW - Neuropsychology

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EP - 1840

JO - NeuroReport

JF - NeuroReport

IS - 8

ER -

Relation of age and apolipoprotein E to cognitive function in Down syndrome adults

Abstract

Keywords

ASJC Scopus subject areas

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