Regulation of skeletal muscle satellite cell proliferation by bovine pituitary fibroblast growth factor

Ronald E. Allen, Michael V. Dodson, Lynda S. Luiten

    Research output: Contribution to journalArticlepeer-review

    120 Scopus citations

    Abstract

    Satellite cells in skeletal muscle have been implicated in muscle growth processes and regeneration. However, very little is known about the regulation of their proliferation and differentiation. The effect of fibroblast growth factor (FGF) on the proliferation of myogenic cells from adult rat skeletal muscle, presumably satellite cells, has been examined, and FGF has been found to be a potent mitogen for these cells. The mitogenic properties of serum were also documented and studied in conjunction with FGF. Even under conditions of maximal stimulation by serum, the addition of FGF caused a substantial increase in proliferation of satellite cells. The additive nature of the FGF and serum-stimulatory activity suggests that FGF-like molecules are not the active agents in serum and that more than one pathway may be involved in stimulating satellite cell proliferation.

    Original languageEnglish (US)
    Pages (from-to)154-160
    Number of pages7
    JournalExperimental Cell Research
    Volume152
    Issue number1
    DOIs
    StatePublished - May 1984

    ASJC Scopus subject areas

    • Cell Biology

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