Regulation of serum 1α,25-dihydroxyvitamin D3 by calcium and phosphate in the rat

Mark R. Hughes, Peter F. Brumbaugh, Mark R. Haussler, Jon E. Wergedal, David J. Baylink

Research output: Contribution to journalArticlepeer-review

242 Scopus citations


A new radioreceptor assay was used to quantify changes in serum concentration of 1α,25-dihydroxyvitamin D3 in rats with low calcium or low phosphate diets. Low availability of either ion elicits a fivefold increase in the circulating concentration of 1α,25- dihydroxyvitamin D3. The enhancement of 1α,25-dihydroxyvitamin D3 concentration in response to calcium deficiency is dependent on the presence of the parathyroid or thyroid glands (or both), suggesting that this effect is mediated by parathyroid hormone. In contrast, the response to phosphate deficiency is independent of these glands and may result from an action of low serum phosphate concentration or some factor associated with phosphate depletion on the renal synthesis of the 1α,25-dihydroxyvitamin D3 hormone.

Original languageEnglish (US)
Pages (from-to)578-580
Number of pages3
Issue number4214
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • General


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