Regulation of isotype switching

Donata Vercelli; Raif S. Geha

doi:10.1016/0952-7915(92)90064-L

Regulation of isotype switching

Donata Vercelli, Raif S. Geha

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particular switch region, and targeting switch recombination.

Original language	English (US)
Pages (from-to)	794-797
Number of pages	4
Journal	Current Opinion in Immunology
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/0952-7915(92)90064-L
State	Published - Dec 1992

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0952-7915(92)90064-L

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@article{d5281ed4ef7e48fe9e1839ea897fa127,

title = "Regulation of isotype switching",

abstract = "In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particular switch region, and targeting switch recombination.",

author = "Donata Vercelli and Geha, {Raif S.}",

note = "Funding Information: D Vercelli is supported by a Burroughs Wellcome Fund Developing Investigator Award in Immunopharmacology of Allergic Diseases.",

year = "1992",

month = dec,

doi = "10.1016/0952-7915(92)90064-L",

language = "English (US)",

volume = "4",

pages = "794--797",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

publisher = "Elsevier Limited",

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T1 - Regulation of isotype switching

AU - Vercelli, Donata

AU - Geha, Raif S.

N1 - Funding Information: D Vercelli is supported by a Burroughs Wellcome Fund Developing Investigator Award in Immunopharmacology of Allergic Diseases.

PY - 1992/12

Y1 - 1992/12

N2 - In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particular switch region, and targeting switch recombination.

AB - In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particular switch region, and targeting switch recombination.

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U2 - 10.1016/0952-7915(92)90064-L

DO - 10.1016/0952-7915(92)90064-L

M3 - Article

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AN - SCOPUS:0027102169

VL - 4

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EP - 797

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

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Regulation of isotype switching

Abstract

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