Regulation of insect P450s in response to phytochemicals

Xianchun Li, Zhongyuan Deng, Xuewei Chen

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Insect herbivores use phytochemicals as signals to induce expression of their phytochemical-detoxifying cytochrome P450 monooxygenases (P450s). The regulatory cascades that transduce phytochemical signals to enhanced expression of P450s are the focus of this review. At least seven signaling pathways, including RTK/MAPK, GPCR/CREB, GPCR/NFκB, ROS/CncC/Keap1, AhR/ARNT, cytosol NR, and nucleus-located NR, may be involved in phytochemical induction of P450s. Constitutive overexpression, overphosphorylation, and/or activation of one or more effectors in the corresponding pathway are common causes of P450 overexpression that lead to phytochemical or insecticide resistance. Future research should pay more attentions to the starting point of each pathway, the number of pathways and their cross talk for a given phytochemical, and the pathways for downregulation of P450s.

Original languageEnglish (US)
Pages (from-to)108-116
Number of pages9
JournalCurrent Opinion in Insect Science
StatePublished - Feb 2021

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Insect Science


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