TY - JOUR
T1 - Regulation of insect P450s in response to phytochemicals
AU - Li, Xianchun
AU - Deng, Zhongyuan
AU - Chen, Xuewei
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/2
Y1 - 2021/2
N2 - Insect herbivores use phytochemicals as signals to induce expression of their phytochemical-detoxifying cytochrome P450 monooxygenases (P450s). The regulatory cascades that transduce phytochemical signals to enhanced expression of P450s are the focus of this review. At least seven signaling pathways, including RTK/MAPK, GPCR/CREB, GPCR/NFκB, ROS/CncC/Keap1, AhR/ARNT, cytosol NR, and nucleus-located NR, may be involved in phytochemical induction of P450s. Constitutive overexpression, overphosphorylation, and/or activation of one or more effectors in the corresponding pathway are common causes of P450 overexpression that lead to phytochemical or insecticide resistance. Future research should pay more attentions to the starting point of each pathway, the number of pathways and their cross talk for a given phytochemical, and the pathways for downregulation of P450s.
AB - Insect herbivores use phytochemicals as signals to induce expression of their phytochemical-detoxifying cytochrome P450 monooxygenases (P450s). The regulatory cascades that transduce phytochemical signals to enhanced expression of P450s are the focus of this review. At least seven signaling pathways, including RTK/MAPK, GPCR/CREB, GPCR/NFκB, ROS/CncC/Keap1, AhR/ARNT, cytosol NR, and nucleus-located NR, may be involved in phytochemical induction of P450s. Constitutive overexpression, overphosphorylation, and/or activation of one or more effectors in the corresponding pathway are common causes of P450 overexpression that lead to phytochemical or insecticide resistance. Future research should pay more attentions to the starting point of each pathway, the number of pathways and their cross talk for a given phytochemical, and the pathways for downregulation of P450s.
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U2 - 10.1016/j.cois.2020.12.003
DO - 10.1016/j.cois.2020.12.003
M3 - Review article
C2 - 33385580
AN - SCOPUS:85098972358
SN - 2214-5745
VL - 43
SP - 108
EP - 116
JO - Current Opinion in Insect Science
JF - Current Opinion in Insect Science
ER -