Regulation of gene expression and mitochondrial dynamics by SMAD

Nirav Shah; Nam Y. Lee

doi:10.1080/23723556.2016.1204492

Regulation of gene expression and mitochondrial dynamics by SMAD

Nirav Shah
, Nam Y. Lee

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.

Original language	English (US)
Article number	e1204492
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1080/23723556.2016.1204492
State	Published - Sep 2 2016
Externally published	Yes

Keywords

MFN2
RIN1
SMAD
mitochondria
transforming growth factor beta

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

Access to Document

10.1080/23723556.2016.1204492

Cite this

@article{6a54eee67ac94ae7953206d1013ab8bd,

title = "Regulation of gene expression and mitochondrial dynamics by SMAD",

abstract = "Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.",

keywords = "MFN2, RIN1, SMAD, mitochondria, transforming growth factor beta",

author = "Nirav Shah and Lee, \{Nam Y.\}",

note = "Publisher Copyright: {\textcopyright} 2016, {\textcopyright} 2016 Taylor \& Francis Group, LLC.",

year = "2016",

month = sep,

day = "2",

doi = "10.1080/23723556.2016.1204492",

language = "English (US)",

volume = "3",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - Regulation of gene expression and mitochondrial dynamics by SMAD

AU - Shah, Nirav

AU - Lee, Nam Y.

PY - 2016/9/2

Y1 - 2016/9/2

N2 - Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.

AB - Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.

KW - MFN2

KW - RIN1

KW - SMAD

KW - mitochondria

KW - transforming growth factor beta

UR - https://www.scopus.com/pages/publications/85050746725

UR - https://www.scopus.com/pages/publications/85050746725#tab=citedBy

U2 - 10.1080/23723556.2016.1204492

DO - 10.1080/23723556.2016.1204492

M3 - Comment/debate

AN - SCOPUS:85050746725

SN - 2372-3556

VL - 3

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 5

M1 - e1204492

ER -

Regulation of gene expression and mitochondrial dynamics by SMAD

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this