Regulation of gene expression and mitochondrial dynamics by SMAD

Nirav Shah; Nam Y. Lee

doi:10.1080/23723556.2016.1204492

Regulation of gene expression and mitochondrial dynamics by SMAD

Nirav Shah, Nam Y. Lee

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.

Original language	English (US)
Article number	e1204492
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1080/23723556.2016.1204492
State	Published - Sep 2 2016

Keywords

MFN2
RIN1
SMAD
mitochondria
transforming growth factor beta

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2016.1204492

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abstract = "Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.",

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AB - Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.

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KW - RIN1

KW - SMAD

KW - mitochondria

KW - transforming growth factor beta

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ER -

Regulation of gene expression and mitochondrial dynamics by SMAD

Abstract

Keywords

ASJC Scopus subject areas

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