Regulation of gene expression and mitochondrial dynamics by SMAD

Nirav Shah, Nam Y. Lee

Research output: Contribution to journalComment/debatepeer-review

2 Scopus citations


Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.

Original languageEnglish (US)
Article numbere1204492
JournalMolecular and Cellular Oncology
Issue number5
StatePublished - Sep 2 2016


  • MFN2
  • RIN1
  • SMAD
  • mitochondria
  • transforming growth factor beta

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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