Regulation of epithelial cell growth by ZBP-89: Potential relevance in pancreatic cancer

Longchuan Bai, Craig Logsdon, Juanita L. Merchant

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


ZBP-89 (ZNF148) is a Zinc finger Binding Protein of 89 kDa that binds GC-rich DNA elements. Originally, it was expression cloned using a DNA element mediating EGF regulation of the gastrin promoter. ZBP-89 functions as both a transcriptional activator and repressor. A variety of extracellular regulators including TGFβ, retinoic acid and butyrate stimulate ZBP-89 gene expression. Butyrate activation of p21WAF1 is potentiated by ZBP-89 through the recruitment of the co-activator p300, while chronic stimulation by butyrate increases ZBP-89 gene expression correlating with cell differentiation. ZBP-89 stimulates growth arrest and apoptosis through its ability to bind the p21WAF1 promoter or its ability to form protein-protein interactions with p53. ZBP-89 protein is elevated in a variety of gastrointestinal cancers as well as the pancreas. In particular, ZBP-89 is normally expressed in pancreatic islets and ducts and in about 30% of pancreatic adenocarcinomas.

Original languageEnglish (US)
Pages (from-to)79-88
Number of pages10
JournalInternational Journal of Gastrointestinal Cancer
Issue number1-3
StatePublished - 2002
Externally publishedYes


  • Apoptosis
  • Cell cycle
  • Gastrin
  • Islet
  • p21
  • p53
  • TGFβ
  • ZNF148

ASJC Scopus subject areas

  • Oncology
  • Endocrinology
  • Gastroenterology


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