Abstract
ZBP-89 (ZNF148) is a Zinc finger Binding Protein of 89 kDa that binds GC-rich DNA elements. Originally, it was expression cloned using a DNA element mediating EGF regulation of the gastrin promoter. ZBP-89 functions as both a transcriptional activator and repressor. A variety of extracellular regulators including TGFβ, retinoic acid and butyrate stimulate ZBP-89 gene expression. Butyrate activation of p21WAF1 is potentiated by ZBP-89 through the recruitment of the co-activator p300, while chronic stimulation by butyrate increases ZBP-89 gene expression correlating with cell differentiation. ZBP-89 stimulates growth arrest and apoptosis through its ability to bind the p21WAF1 promoter or its ability to form protein-protein interactions with p53. ZBP-89 protein is elevated in a variety of gastrointestinal cancers as well as the pancreas. In particular, ZBP-89 is normally expressed in pancreatic islets and ducts and in about 30% of pancreatic adenocarcinomas.
Original language | English (US) |
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Pages (from-to) | 79-88 |
Number of pages | 10 |
Journal | International Journal of Gastrointestinal Cancer |
Volume | 31 |
Issue number | 1-3 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Apoptosis
- Cell cycle
- Gastrin
- Islet
- TGFβ
- ZNF148
- p21
- p53
ASJC Scopus subject areas
- Oncology
- Endocrinology
- Gastroenterology