TY - JOUR
T1 - Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases
T2 - a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO)
AU - Yu, Ai Ming
AU - Ingelman-Sundberg, Magnus
AU - Cherrington, Nathan J.
AU - Aleksunes, Lauren M.
AU - Zanger, Ulrich M.
AU - Xie, Wen
AU - Jeong, Hyunyoung
AU - Morgan, Edward M.
AU - Turnbaugh, Peter J.
AU - Klaassen, Curtis D.
AU - Bhatt, Aadra P.
AU - Redinbo, Matthew R.
AU - Hao, Pengying
AU - Waxman, David J.
AU - Wang, Li
AU - Zhong, Xiao bo
N1 - Publisher Copyright:
© 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Variations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21st International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2–6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity, and discussed potential implications to personalized medications. A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption, distribution, metabolism, and excretion (ADME) and drug response. Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented. In addition, the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed. These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research.
AB - Variations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21st International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2–6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity, and discussed potential implications to personalized medications. A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption, distribution, metabolism, and excretion (ADME) and drug response. Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented. In addition, the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed. These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research.
KW - Disease
KW - Drug metabolism and toxicity
KW - Epigenetics
KW - Genetics
KW - Gut microbiota
KW - Long non-coding RNAs
KW - Personalized medication
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U2 - 10.1016/j.apsb.2016.12.006
DO - 10.1016/j.apsb.2016.12.006
M3 - Article
AN - SCOPUS:85011026233
SN - 2211-3835
VL - 7
SP - 241
EP - 248
JO - Acta Pharmaceutica Sinica B
JF - Acta Pharmaceutica Sinica B
IS - 2
ER -