TY - JOUR
T1 - Regional myocardial perfusion at rest and during intracoronary papaverine in patients with coronary artery disease
AU - Goldman, Steven
AU - Henry, Robert
AU - Ovitt, Theron
AU - Friedman, Mark J.
AU - Rosenfeld, Alan
AU - Daly, Michael
N1 - Funding Information:
of Internal Medicine Center and University grants from the Arizona the Veterans Administration. Sept. 22, 1980; revision
Funding Information:
From the Departments Administration Medical Supported by research Heart Association and Received for publication accepted July 10, 1981. Reprint requests: Steven Tucson. AZ 8.5723.
PY - 1983/3
Y1 - 1983/3
N2 - Regional myocardial perfusion was measured in 32 patients with the xenon-133 washout technique at rest and after 5 mg of intracoronary papaverine. Areas of decreased perfusion and/or decreased vasodilation were identified visually from computer-generated functional images. The locations of arteries and stenoses, obtained from identically positioned cineangiograms, were overlaid on the functional images. Perfusion rates for 62 myocardial regions were calculated and correlated with the percentage of stenosis. There was no association between degree of stenosis and perfusion at rest. Regional myocardial perfusion increased after papaverine in regions supplied by coronary arteries without stenoses (0% to 25%), 88.6 ± 4.7 ml/min/100 gm. This increase was significantly greater (p < 0.001) than the increase in regions supplied by 51% to 75% stenoses (23.7 ± 6.3 ml/min/100 gm), or 76% to 99% stenoses (12.9 ± 6.3 ml/min/100 gm), or 100% stenoses (2.5 ± 3.8 ml/min/100 gm). Thus there was an inverse relationship between the increase in myocardial perfusion stimulated by papaverine and the degree of coronary artery stenosis measured angiographically. In regions supplied by two stenoses in series, vasodilation produced less of an increase than a single stenosis of a similar degree.
AB - Regional myocardial perfusion was measured in 32 patients with the xenon-133 washout technique at rest and after 5 mg of intracoronary papaverine. Areas of decreased perfusion and/or decreased vasodilation were identified visually from computer-generated functional images. The locations of arteries and stenoses, obtained from identically positioned cineangiograms, were overlaid on the functional images. Perfusion rates for 62 myocardial regions were calculated and correlated with the percentage of stenosis. There was no association between degree of stenosis and perfusion at rest. Regional myocardial perfusion increased after papaverine in regions supplied by coronary arteries without stenoses (0% to 25%), 88.6 ± 4.7 ml/min/100 gm. This increase was significantly greater (p < 0.001) than the increase in regions supplied by 51% to 75% stenoses (23.7 ± 6.3 ml/min/100 gm), or 76% to 99% stenoses (12.9 ± 6.3 ml/min/100 gm), or 100% stenoses (2.5 ± 3.8 ml/min/100 gm). Thus there was an inverse relationship between the increase in myocardial perfusion stimulated by papaverine and the degree of coronary artery stenosis measured angiographically. In regions supplied by two stenoses in series, vasodilation produced less of an increase than a single stenosis of a similar degree.
UR - https://www.scopus.com/pages/publications/0020673585
UR - https://www.scopus.com/pages/publications/0020673585#tab=citedBy
U2 - 10.1016/0002-8703(83)90352-6
DO - 10.1016/0002-8703(83)90352-6
M3 - Article
C2 - 6829399
AN - SCOPUS:0020673585
SN - 0002-8703
VL - 105
SP - 372
EP - 379
JO - American Heart Journal
JF - American Heart Journal
IS - 3
ER -