Regional dependence of morphine-induced μ-opiate receptor down-regulation in perinatal rat brain

Ronald P. Hammer; Joruel V. Seatriz; Arleen R. Ricalde

doi:10.1016/0014-2999(91)90178-S

Regional dependence of morphine-induced μ-opiate receptor down-regulation in perinatal rat brain

Ronald P. Hammer, Joruel V. Seatriz, Arleen R. Ricalde

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The effect of perinatal morphine administration was examined in various brain regions using in vitro receptor autoradiography. Morphine was administered by continuous s.c. infusion of 10 mg/kg per day; brains of offspring were examined at five days of age. Morphine exposure reduced μ-receptor binding density in the preoptic area of hypothalamus, but not in the primary somatosensory cortex. μ-Receptor density was greater in the medial preoptic area of females than males, and in superficial layers of cortex in males than females. The results suggest that morphine has selective regional effects on μ-receptor ontogeny in rat brain.

Original language	English (US)
Pages (from-to)	253-256
Number of pages	4
Journal	European Journal of Pharmacology
Volume	209
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(91)90178-S
State	Published - Dec 17 1991
Externally published	Yes

Keywords

Developement
Hypothalamus
Opiates
[H]DAGO binding

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(91)90178-S

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title = "Regional dependence of morphine-induced μ-opiate receptor down-regulation in perinatal rat brain",

abstract = "The effect of perinatal morphine administration was examined in various brain regions using in vitro receptor autoradiography. Morphine was administered by continuous s.c. infusion of 10 mg/kg per day; brains of offspring were examined at five days of age. Morphine exposure reduced μ-receptor binding density in the preoptic area of hypothalamus, but not in the primary somatosensory cortex. μ-Receptor density was greater in the medial preoptic area of females than males, and in superficial layers of cortex in males than females. The results suggest that morphine has selective regional effects on μ-receptor ontogeny in rat brain.",

keywords = "Developement, Hypothalamus, Opiates, [H]DAGO binding",

author = "Hammer, {Ronald P.} and Seatriz, {Joruel V.} and Ricalde, {Arleen R.}",

note = "Funding Information: This work was supported by USPHS awards DA04081 and Research Career Development Award NS01161 to RPH. JVS was supported in part by USPHS-MARC Predoctoral Fellowship GM07684, and ARR was supported by USPHS-MBRS Predoctoral Fellowship GM08125.",

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AU - Hammer, Ronald P.

AU - Seatriz, Joruel V.

AU - Ricalde, Arleen R.

N1 - Funding Information: This work was supported by USPHS awards DA04081 and Research Career Development Award NS01161 to RPH. JVS was supported in part by USPHS-MARC Predoctoral Fellowship GM07684, and ARR was supported by USPHS-MBRS Predoctoral Fellowship GM08125.

PY - 1991/12/17

Y1 - 1991/12/17

N2 - The effect of perinatal morphine administration was examined in various brain regions using in vitro receptor autoradiography. Morphine was administered by continuous s.c. infusion of 10 mg/kg per day; brains of offspring were examined at five days of age. Morphine exposure reduced μ-receptor binding density in the preoptic area of hypothalamus, but not in the primary somatosensory cortex. μ-Receptor density was greater in the medial preoptic area of females than males, and in superficial layers of cortex in males than females. The results suggest that morphine has selective regional effects on μ-receptor ontogeny in rat brain.

AB - The effect of perinatal morphine administration was examined in various brain regions using in vitro receptor autoradiography. Morphine was administered by continuous s.c. infusion of 10 mg/kg per day; brains of offspring were examined at five days of age. Morphine exposure reduced μ-receptor binding density in the preoptic area of hypothalamus, but not in the primary somatosensory cortex. μ-Receptor density was greater in the medial preoptic area of females than males, and in superficial layers of cortex in males than females. The results suggest that morphine has selective regional effects on μ-receptor ontogeny in rat brain.

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KW - Hypothalamus

KW - Opiates

KW - [H]DAGO binding

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Regional dependence of morphine-induced μ-opiate receptor down-regulation in perinatal rat brain

Abstract

Keywords

ASJC Scopus subject areas

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