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Regeneration of Sensory Cells of Adult Mammalian Inner Ear

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Irreversible loss of hair cells and their innervating spiral ganglion neurons is the major reason for hearing loss. Attempts at integrating new supplementary cell sources into the damaged inner ear have been tested extensively. This chapter reviews the history of available cell sources and their achievements, limitations, and future developments for hearing rehabilitation. It addressed issues regarding the “self-repair” of mammalian inner ear sensory epithelium, including (1) recruitment of the in situ proliferation and differentiation of endogenous cells at the damaged site and (2) autologous transplantation, which offer new optimism for helping hearing-impaired individuals.

Original languageEnglish (US)
Title of host publicationStem Cell Biology and Regenerative Medicine
PublisherSpringer Nature
Pages89-101
Number of pages13
DOIs
StatePublished - 2011

Publication series

NameStem Cell Biology and Regenerative Medicine
VolumePart F4849
ISSN (Print)2196-8985
ISSN (Electronic)2196-8993

Keywords

  • Inner ear
  • Rehabilitation
  • Sensory epithelium
  • Stem cells

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

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