Refuges of conventional host plants counter dominant resistance of cotton bollworm to transgenic Bt cotton

Fang Guan, Xiaoguang Dai, Bofeng Hou, Shuwen Wu, Yihua Yang, Yanhui Lu, Kongming Wu, Bruce E. Tabashnik, Yidong Wu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Transgenic crops have revolutionized insect pest control, but evolution of resistance by pests threatens their continued success. The primary strategy for combating pest resistance to crops producing insecticidal proteins from Bacillus thuringiensis (Bt) uses refuges of non-Bt host plants to allow survival of susceptible insects. The prevailing paradigm is that refuges delay resistance that is rare and recessively inherited. However, we discovered refuges countered resistance to Bt cotton that was neither rare nor recessive. In a 15-year field study of the cotton bollworm, the frequency of a mutation conferring dominant resistance to Bt cotton surged 100-fold from 2006 to 2016 yet did not rise from 2016 to 2020. Computer simulations indicate the increased refuge percentage from 2016 to 2020 is sufficient to explain the observed halt in the evolution of resistance. The results also demonstrate the efficacy of a Bt crop can be sustained by non-Bt refuges of other crops.

Original languageEnglish (US)
Article number106768
JournaliScience
Volume26
Issue number5
DOIs
StatePublished - May 19 2023

Keywords

  • Evolutionary ecology
  • Interaction of plants with organisms
  • Sequence analysis

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Refuges of conventional host plants counter dominant resistance of cotton bollworm to transgenic Bt cotton'. Together they form a unique fingerprint.

Cite this