Refractory insomnia in an adolescent with total blindness

Andrew S. Tubbs, Michael A. Grandner, Daniel Combs

Research output: Contribution to journalArticlepeer-review


We present a totally blind adolescent with refractory insomnia due to a combination of Non-24 hour sleepwake disorder and restless leg syndrome that was successfully treated with tasimelteon, iron replacement, and gabapentin. To our knowledge, this is the first published report of treatment of N24 with tasimelteon in an adolescent. In addition, this case highlights the importance of recognizing and treating multifactorial causes of insomnia.

Original languageEnglish (US)
Pages (from-to)201-204
Number of pages4
JournalYale Journal of Biology and Medicine
Issue number2
StatePublished - 2019


  • Adolescent
  • Insomnia
  • Non-24 hour sleep-wake disorder
  • Tasimelteon

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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