Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency

Donald C. Vinh; Fares Masannat; Robert B. Dzioba; John N. Galgiani; Steven M. Holland

doi:10.1086/605532

Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency

Donald C. Vinh
, Fares Masannat
, Robert B. Dzioba
, John N. Galgiani
, Steven M. Holland

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.

Original language	English (US)
Pages (from-to)	e62-e65
Journal	Clinical Infectious Diseases
Volume	49
Issue number	6
DOIs	https://doi.org/10.1086/605532
State	Published - Sep 15 2009

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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@article{02e440788c4642fabf16e7555dfcc457,

title = "Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency",

abstract = "Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.",

author = "Vinh, \{Donald C.\} and Fares Masannat and Dzioba, \{Robert B.\} and Galgiani, \{John N.\} and Holland, \{Steven M.\}",

note = "Funding Information: Financial support. Canadian Institutes of Health Research (CIHR fellowship for D.C.V.); Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH; US Department of Veterans Affairs. Potential conflicts of interest. All authors: no conflicts.",

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AU - Vinh, Donald C.

AU - Masannat, Fares

AU - Dzioba, Robert B.

AU - Galgiani, John N.

AU - Holland, Steven M.

N1 - Funding Information: Financial support. Canadian Institutes of Health Research (CIHR fellowship for D.C.V.); Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH; US Department of Veterans Affairs. Potential conflicts of interest. All authors: no conflicts.

PY - 2009/9/15

Y1 - 2009/9/15

N2 - Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.

AB - Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.

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UR - https://www.scopus.com/pages/publications/70049098532#tab=citedBy

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 6

ER -

Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency

Abstract

ASJC Scopus subject areas

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