Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency

Donald C. Vinh; Fares Masannat; Robert B. Dzioba; John N. Galgiani; Steven M. Holland

doi:10.1086/605532

Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency

Donald C. Vinh, Fares Masannat, Robert B. Dzioba, John N. Galgiani, Steven M. Holland

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.

Original language	English (US)
Pages (from-to)	e62-e65
Journal	Clinical Infectious Diseases
Volume	49
Issue number	6
DOIs	https://doi.org/10.1086/605532
State	Published - Sep 15 2009

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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title = "Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency",

abstract = "Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.",

author = "Vinh, {Donald C.} and Fares Masannat and Dzioba, {Robert B.} and Galgiani, {John N.} and Holland, {Steven M.}",

note = "Funding Information: Financial support. Canadian Institutes of Health Research (CIHR fellowship for D.C.V.); Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH; US Department of Veterans Affairs. Potential conflicts of interest. All authors: no conflicts.",

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AU - Masannat, Fares

AU - Dzioba, Robert B.

AU - Galgiani, John N.

AU - Holland, Steven M.

N1 - Funding Information: Financial support. Canadian Institutes of Health Research (CIHR fellowship for D.C.V.); Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH; US Department of Veterans Affairs. Potential conflicts of interest. All authors: no conflicts.

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Y1 - 2009/9/15

N2 - Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.

AB - Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.

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Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-γ receptor 1 deficiency

Abstract

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