Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-γ receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-γ axis appears to be critical for control of coccidioidomycosis.
|Original language||English (US)|
|Journal||Clinical Infectious Diseases|
|State||Published - Sep 15 2009|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases