Reflectance full Mueller matrix polarimetry for microstructural validation of diffusion magnetic resonance imaging

Justina Bonaventura, Kellys Morara, Rhea Carlson, Courtney Comrie, Elizabeth Hutchinson, Travis W. Sawyer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Knowledge of fiber microstructure and orientation in the brain is critical for understanding the pathogenesis and progression of neurodegenerative diseases such as Alzheimer's Disease. Diffusion magnetic resonance imaging (dMRI) is a noninvasive imaging modality that can generate mappings of nerve fiber orientation. Due to rigorous levels of mathematical modeling involved in reconstructing dMRI data; and limited spatial resolution, there arises a need to validate the biological accuracy of collected dMRI data. Polarized light imaging (PLI) has been shown to have potential for microstructural validation due to the anisotropy in many biological tissues, particularly in myelin sheaths surrounding nerve fibers in the brain. Using PLI for this purpose is appealing because it is directly sensitive to tissue structure and can be done at high resolution. While several studies have had success using PLI for fiber mapping, continuing to advance this modality, particularly reflectance based PLI systems, could provide a valuable avenue for in vivo neural imaging. In order to reach the full potential of reflectance PLI systems, some key questions remain such as the ability of PLI to resolve crossing fibers, and the sensitivity of reflectance PLI to fiber inclination. Tissue phantoms are one potential method to isolate these issues in order to investigate them. In this proceeding, a five-wavelength reflectance Mueller Matrix polarimeter is used for imaging of promising PLI tissue phantoms as well as regions of interest in fixed ferret brain samples. The retardance, diattenuation and depolarization mappings are derived from the Mueller matrix and studied in order to assess the sensitivity of this polarimeter configuration to different fiber orientations.

Original languageEnglish (US)
Title of host publicationPolarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023
EditorsJessica C. Ramella-Roman, Hui Ma, Tatiana Novikova, Daniel S. Elson, I. Alex Vitkin
PublisherSPIE
ISBN (Electronic)9781510658691
DOIs
StatePublished - 2023
EventPolarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023 - San Francisco, United States
Duration: Jan 28 2023Jan 29 2023

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12382
ISSN (Print)1605-7422

Conference

ConferencePolarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023
Country/TerritoryUnited States
CitySan Francisco
Period1/28/231/29/23

Keywords

  • Diffusion Magnetic Resonance Imaging
  • Mueller Matrix Polarimetry
  • Polarized Light Imaging
  • Reflectance Polarimetry
  • Tissue Phantoms

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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