Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice

Guan Jie Chen; Lucas L. Colombo; Maria C. Lopez; Ronald R. Watson

doi:10.1016/0304-3835(93)90236-3

Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice

Guan Jie Chen, Lucas L. Colombo, Maria C. Lopez, Ronald R. Watson

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and γ-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.

Original language	English (US)
Pages (from-to)	147-150
Number of pages	4
Journal	Cancer Letters
Volume	74
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(93)90236-3
State	Published - Nov 1 1993
Externally published	Yes

Keywords

Oncomouse
Tumor necrosis factor
V-Ha-ras oncogene
γ-Interferon

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(93)90236-3

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title = "Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice",

abstract = "Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and γ-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.",

keywords = "Oncomouse, Tumor necrosis factor, V-Ha-ras oncogene, γ-Interferon",

author = "Chen, {Guan Jie} and Colombo, {Lucas L.} and Lopez, {Maria C.} and Watson, {Ronald R.}",

note = "Funding Information: This researchw as supported by NIH by Wallace Genetics Foundation, Inc.",

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T1 - Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice

AU - Chen, Guan Jie

AU - Colombo, Lucas L.

AU - Lopez, Maria C.

AU - Watson, Ronald R.

N1 - Funding Information: This researchw as supported by NIH by Wallace Genetics Foundation, Inc.

PY - 1993/11/1

Y1 - 1993/11/1

N2 - Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and γ-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.

AB - Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and γ-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.

KW - Oncomouse

KW - Tumor necrosis factor

KW - V-Ha-ras oncogene

KW - γ-Interferon

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Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice

Abstract

Keywords

ASJC Scopus subject areas

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