Reduction is the New Youth: The Effect of Polyphenols on Brain Aging and Diseases

Lakshana Sreenivasan, Ronald Ross Watson

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Polyphenols are secondary metabolites produced by plants. They have great reduction potency that plays an important role in brain aging and in neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease. Normal aging is accompanied by proper cognitive function and health of the brain. Oxidative stress and damage that lead to neurodegenerative diseases are due to ROS and RNS. These reactive species play a significant role in deciphering the mechanism and physiological properties of polyphenols. In this review, the structure and mechanism of basic polyphenol activity is discussed. The antioxidant properties of various polyphenols can be tested to uncover the most potent bioavailable polyphenol. Different polyphenolic compounds are also studied to understand the mechanisms and pathways adopted by them for treating and preventing neurodegenerative diseases.

Original languageEnglish (US)
Title of host publicationBioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease
Subtitle of host publicationPrevention and Therapy
PublisherElsevier Inc.
Number of pages4
ISBN (Electronic)9780124115293
ISBN (Print)9780124114623
StatePublished - 2015


  • Brain aging
  • Flavonoids
  • Neurodegenerative diseases
  • Oxidation
  • Polyphenols
  • ROS

ASJC Scopus subject areas

  • General Medicine


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