Abstract
ROS and RNS are important mediators of signaling pathways in the endothelium. Specific members of the TRP superfamily of cation channels act as important Ca2+ influx pathways in endothelial cells and are involved in endothelium-dependent vasodilation, regulation of barrier permeability, and angiogenesis. ROS and RNS can modulate the activity of certain TRP channels mainly by modifying specific cysteine residues or by stimulating the production of second messengers. In this review, we highlight the recent literature describing redox regulation of TRP channel activity in endothelial cells as well as the physiological importance of these pathways and implication for cardiovascular diseases.
Original language | English (US) |
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Article number | e12329 |
Journal | Microcirculation |
Volume | 24 |
Issue number | 3 |
DOIs | |
State | Published - Apr 2017 |
Externally published | Yes |
Keywords
- Ca influx
- TRP channels
- endothelial cells
- redox signaling
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cardiology and Cardiovascular Medicine
- Physiology (medical)