Redox regulation of transient receptor potential channels in the endothelium

Paulo Wagner Pires, Scott Earley

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

ROS and RNS are important mediators of signaling pathways in the endothelium. Specific members of the TRP superfamily of cation channels act as important Ca2+ influx pathways in endothelial cells and are involved in endothelium-dependent vasodilation, regulation of barrier permeability, and angiogenesis. ROS and RNS can modulate the activity of certain TRP channels mainly by modifying specific cysteine residues or by stimulating the production of second messengers. In this review, we highlight the recent literature describing redox regulation of TRP channel activity in endothelial cells as well as the physiological importance of these pathways and implication for cardiovascular diseases.

Original languageEnglish (US)
Article numbere12329
JournalMicrocirculation
Volume24
Issue number3
DOIs
StatePublished - Apr 2017
Externally publishedYes

Keywords

  • Ca influx
  • TRP channels
  • endothelial cells
  • redox signaling

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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