Redox regulation by NRF2 in aging and disease

Cody J. Schmidlin, Matthew B. Dodson, Lalitha Madhavan, Donna D. Zhang

Research output: Contribution to journalReview articlepeer-review

290 Scopus citations


NRF2, a transcription factor that has been deemed the master regulator of cellular redox homeostasis, declines with age. NRF2 transcriptionally upregulates genes that combat oxidative stress; therefore, loss of NRF2 allows oxidative stress to go unmitigated and drive the aging phenotype. Oxidative stress is a common theme among the key features associated with the aging process, collectively referred to as the “Hallmarks of Aging”, as it disrupts proteostasis, alters genomic stability, and leads to cell death. In this review, we outline the role that oxidative stress and the reduction of NRF2 play in each of the Hallmarks of Aging, including how they contribute to the onset of neurodegenerative disorders, cancer, and other age-related pathologies.

Original languageEnglish (US)
Pages (from-to)702-707
Number of pages6
JournalFree Radical Biology and Medicine
StatePublished - Apr 2019


  • Age-related pathologies
  • Aging
  • Antioxidant response element (ARE)
  • Cancer
  • KEAP1
  • NRF2
  • Neurodegeneration
  • Oxidative stress
  • Redox regulation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)


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