Redefining actin dynamics of the pointed-end complex in striated muscle

Jessika Iwanski, Carol C. Gregorio, Mert Colpan

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


Striated muscle is intricately designed to provide efficient and powerful muscle contractions. Recently, a long sought-after missing component of the thin filament pointed-end machinery was discovered: cyclase-associated protein 2 (CAP2). CAP2 was identified as a crucial contributor to actin polymerization, striated muscle development, and severe muscle disease when mutated.

Original languageEnglish (US)
Pages (from-to)708-711
Number of pages4
JournalTrends in Cell Biology
Issue number9
StatePublished - Sep 2021


  • actin
  • muscle
  • myopathy
  • sarcomere
  • thin filament

ASJC Scopus subject areas

  • Cell Biology


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