Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations

B. M. Ciminelli; F. Pompei; P. Malaspina; M. Hammer; F. Persichetti; P. F. Pignatti; A. Palena; N. Anagnou; G. Guanti; C. Jodice; L. Terrenato; A. Novelletto

doi:10.1007/BF00173177

Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations

B. M. Ciminelli, F. Pompei, P. Malaspina, M. Hammer, F. Persichetti, P. F. Pignatti, A. Palena, N. Anagnou, G. Guanti, C. Jodice, L. Terrenato, A. Novelletto

Arizona Research Labs

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The haplotypes at four polymorphic loci of theY chromosome were determined in 245 Caucasian males from 12 subpopulations. The data show that haplotype radiation occurred among Caucasians. Haplotype radiation was accompanied by recurrent mutations at STR loci that caused partial randomization of haplotype structure. The present distribution of alleles at short tandem repeats (STRs) can be explained by a mutation pattern similar to those described for autosomal STRs. The degree of variation among groups of subpopulations was assayed by using the Analysis of Molecular Variance. The results confirm a faster divergence of the Y chromosome as compared to the rest of the genome.

Original language	English (US)
Pages (from-to)	966-973
Number of pages	8
Journal	Journal of Molecular Evolution
Volume	41
Issue number	6
DOIs	https://doi.org/10.1007/BF00173177
State	Published - Dec 1995

Keywords

Human Y chromosome
Human radiation
Single tandem repeats
Y polymorphisms

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics

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10.1007/BF00173177

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title = "Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations",

abstract = "The haplotypes at four polymorphic loci of theY chromosome were determined in 245 Caucasian males from 12 subpopulations. The data show that haplotype radiation occurred among Caucasians. Haplotype radiation was accompanied by recurrent mutations at STR loci that caused partial randomization of haplotype structure. The present distribution of alleles at short tandem repeats (STRs) can be explained by a mutation pattern similar to those described for autosomal STRs. The degree of variation among groups of subpopulations was assayed by using the Analysis of Molecular Variance. The results confirm a faster divergence of the Y chromosome as compared to the rest of the genome.",

keywords = "Human Y chromosome, Human radiation, Single tandem repeats, Y polymorphisms",

author = "Ciminelli, {B. M.} and F. Pompei and P. Malaspina and M. Hammer and F. Persichetti and Pignatti, {P. F.} and A. Palena and N. Anagnou and G. Guanti and C. Jodice and L. Terrenato and A. Novelletto",

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doi = "10.1007/BF00173177",

language = "English (US)",

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T1 - Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations

AU - Ciminelli, B. M.

AU - Pompei, F.

AU - Malaspina, P.

AU - Hammer, M.

AU - Persichetti, F.

AU - Pignatti, P. F.

AU - Palena, A.

AU - Anagnou, N.

AU - Guanti, G.

AU - Jodice, C.

AU - Terrenato, L.

AU - Novelletto, A.

PY - 1995/12

Y1 - 1995/12

N2 - The haplotypes at four polymorphic loci of theY chromosome were determined in 245 Caucasian males from 12 subpopulations. The data show that haplotype radiation occurred among Caucasians. Haplotype radiation was accompanied by recurrent mutations at STR loci that caused partial randomization of haplotype structure. The present distribution of alleles at short tandem repeats (STRs) can be explained by a mutation pattern similar to those described for autosomal STRs. The degree of variation among groups of subpopulations was assayed by using the Analysis of Molecular Variance. The results confirm a faster divergence of the Y chromosome as compared to the rest of the genome.

AB - The haplotypes at four polymorphic loci of theY chromosome were determined in 245 Caucasian males from 12 subpopulations. The data show that haplotype radiation occurred among Caucasians. Haplotype radiation was accompanied by recurrent mutations at STR loci that caused partial randomization of haplotype structure. The present distribution of alleles at short tandem repeats (STRs) can be explained by a mutation pattern similar to those described for autosomal STRs. The degree of variation among groups of subpopulations was assayed by using the Analysis of Molecular Variance. The results confirm a faster divergence of the Y chromosome as compared to the rest of the genome.

KW - Human Y chromosome

KW - Human radiation

KW - Single tandem repeats

KW - Y polymorphisms

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Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations

Abstract

Keywords

ASJC Scopus subject areas

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