Recovery from Hepatorenal Syndrome after Orthotopic Liver Transplantation

Shunzaburo Iwatsuki, Mordecai M. Popovtzer, Jacques L. Corman, Makoto Ishikawa, Charles W. Putnam, Fred H. Katz, Thomas E. Starzl

Research output: Contribution to journalArticlepeer-review

217 Scopus citations


Three patients with progressive renal failure and advanced hepatic insufficiency due to cirrhosis of the liver underwent orthotopic liver transplantation. All three patients had immediate improvement in hepatic function and within two weeks after liver replacement regained nearly normal kidney function. However, the renal recovery was delayed in each case, and its course was not uniform. Plasma renin activity was high, and renin substrate was low before transplantation in one case in which these measurements were obtained; both returned to normal soon after liver replacement. (N Engl J Med 289:1155–1159, 1973).

Original languageEnglish (US)
Pages (from-to)1155-1159
Number of pages5
JournalNew England Journal of Medicine
Issue number22
StatePublished - Nov 29 1973
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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