Receptor specificity defines algogenic properties of propofol and fospropofol

Amol Patwardhan, Rebecca Edelmayer, Emil Annabi, Theodore Price, Phil Malan, Gregory Dussor

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Propofol-evoked injection site pain is not observed with fospropofol. We hypothesized that unlike propofol, fospropofol does not activate the irritant receptor, transient receptor potential 1 (TRPA1). Methods: We tested the hypothesis using electrophysiology and behavioral studies. Results: Our data demonstrate that propofol (100 μM) evokes an inward current only in TRPA1-expressing neurons. However, fospropofol (100 μM and 1 mM) is unable to evoke depolarizing currents in either TRPA1-positive or TRPA1-negative neurons. Both propofol and fospropofol produced general anesthesia. Conclusions: The lack of algogenic activity in fospropofol is most likely the result of its inability to activate TRPA1 on nociceptors.

Original languageEnglish (US)
Pages (from-to)837-840
Number of pages4
JournalAnesthesia and analgesia
Issue number4
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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