Recent progress toward understanding the role of ZIP14 in regulating systemic manganese homeostasis

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

ZIP14 is a metal transporter essential for the regulation of body manganese homeostasis. The physiological functions of ZIP14 have been uncovered mainly through two lines of in vivo studies that examined the phenotypes of ZIP14 loss, including studies of humans with ZIP14 mutations and animals with ZIP14 deficiency. This mini review aims at presenting an updated view of the important advances made towards understanding the genetic and pathological mechanisms of brain manganese overload caused by ZIP14 deficiency.

Original languageEnglish (US)
Pages (from-to)2332-2338
Number of pages7
JournalComputational and Structural Biotechnology Journal
Volume21
DOIs
StatePublished - Jan 2023

Keywords

  • Manganese
  • Nutrition
  • SLC39A14
  • ZIP14

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Genetics
  • Computer Science Applications

Fingerprint

Dive into the research topics of 'Recent progress toward understanding the role of ZIP14 in regulating systemic manganese homeostasis'. Together they form a unique fingerprint.

Cite this