Recent insights concerning autophagy and endothelial cell nitric oxide generation

Seul Ki Park; Jae Min Cho; Sohom Mookherjee; Paulo W. Pires; John David Symons

doi:10.1016/j.cophys.2022.100614

Recent insights concerning autophagy and endothelial cell nitric oxide generation

Seul Ki Park, Jae Min Cho, Sohom Mookherjee, Paulo W. Pires, John David Symons

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Although endothelial cell (EC) dysfunction contributes to the etiology of more diseases than any other tissue in the body, EC metabolism is an understudied therapeutic target. Evidence regarding the important role of autophagy in maintaining EC homeostasis is accumulating rapidly. Here, we focus on advances over the past two years regarding how EC autophagy mediates EC nitric oxide generation in the context of aging and cardiovascular complications, including coronary artery disease, aneurysm, and stroke. In addition, insight concerning the efficacy of maneuvers designed to boost EC autophagy in an effort to combat cardiovascular complications associated with repressed EC autophagy is discussed.

Original language	English (US)
Article number	100614
Journal	Current Opinion in Physiology
Volume	30
DOIs	https://doi.org/10.1016/j.cophys.2022.100614
State	Published - Dec 2022
Externally published	Yes

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.1016/j.cophys.2022.100614

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title = "Recent insights concerning autophagy and endothelial cell nitric oxide generation",

abstract = "Although endothelial cell (EC) dysfunction contributes to the etiology of more diseases than any other tissue in the body, EC metabolism is an understudied therapeutic target. Evidence regarding the important role of autophagy in maintaining EC homeostasis is accumulating rapidly. Here, we focus on advances over the past two years regarding how EC autophagy mediates EC nitric oxide generation in the context of aging and cardiovascular complications, including coronary artery disease, aneurysm, and stroke. In addition, insight concerning the efficacy of maneuvers designed to boost EC autophagy in an effort to combat cardiovascular complications associated with repressed EC autophagy is discussed.",

author = "Park, \{Seul Ki\} and Cho, \{Jae Min\} and Sohom Mookherjee and Pires, \{Paulo W.\} and Symons, \{John David\}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = dec,

doi = "10.1016/j.cophys.2022.100614",

language = "English (US)",

volume = "30",

journal = "Current Opinion in Physiology",

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AU - Park, Seul Ki

AU - Cho, Jae Min

AU - Mookherjee, Sohom

AU - Pires, Paulo W.

AU - Symons, John David

PY - 2022/12

Y1 - 2022/12

N2 - Although endothelial cell (EC) dysfunction contributes to the etiology of more diseases than any other tissue in the body, EC metabolism is an understudied therapeutic target. Evidence regarding the important role of autophagy in maintaining EC homeostasis is accumulating rapidly. Here, we focus on advances over the past two years regarding how EC autophagy mediates EC nitric oxide generation in the context of aging and cardiovascular complications, including coronary artery disease, aneurysm, and stroke. In addition, insight concerning the efficacy of maneuvers designed to boost EC autophagy in an effort to combat cardiovascular complications associated with repressed EC autophagy is discussed.

AB - Although endothelial cell (EC) dysfunction contributes to the etiology of more diseases than any other tissue in the body, EC metabolism is an understudied therapeutic target. Evidence regarding the important role of autophagy in maintaining EC homeostasis is accumulating rapidly. Here, we focus on advances over the past two years regarding how EC autophagy mediates EC nitric oxide generation in the context of aging and cardiovascular complications, including coronary artery disease, aneurysm, and stroke. In addition, insight concerning the efficacy of maneuvers designed to boost EC autophagy in an effort to combat cardiovascular complications associated with repressed EC autophagy is discussed.

UR - https://www.scopus.com/pages/publications/85142194987

UR - https://www.scopus.com/inward/citedby.url?scp=85142194987&partnerID=8YFLogxK

U2 - 10.1016/j.cophys.2022.100614

DO - 10.1016/j.cophys.2022.100614

M3 - Review article

AN - SCOPUS:85142194987

SN - 2468-8681

VL - 30

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

M1 - 100614

ER -

Recent insights concerning autophagy and endothelial cell nitric oxide generation

Abstract

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