Recent developments in multimodality fluorescence imaging probes

Jianhong Zhao, Junwei Chen, Shengnan Ma, Qianqian Liu, Lixian Huang, Xiani Chen, Kaiyan Lou, Wei Wang

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations

Abstract

Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of optical fluorescence imaging (OFI) probe integration with other imaging modalities such as X-ray computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and photoacoustic imaging (PAI). The imaging technologies are briefly described in order to introduce the strengths and limitations of each techniques and the need for further multimodality optical imaging probe development. The emphasis of this account is placed on how design strategies are currently implemented to afford physicochemically and biologically compatible multimodality optical fluorescence imaging probes. We also present studies that overcame intrinsic disadvantages of each imaging technique by multimodality approach with improved detection sensitivity and accuracy.

Original languageEnglish (US)
Pages (from-to)320-338
Number of pages19
JournalActa Pharmaceutica Sinica B
Volume8
Issue number3
DOIs
StatePublished - May 2018
Externally publishedYes

Keywords

  • Computed tomography
  • Fluorescence
  • Magnetic resonance imaging
  • Multimodality
  • Nanoprobe
  • Near-infrared fluorescence
  • Optical imaging
  • Photoacoustic imaging
  • Positron emission tomography
  • Single-photon emission computed tomography

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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