Recent advances in mass spectrometry analytical techniques for per- and polyfluoroalkyl substances (PFAS)

Shenglan Jia, Mauricius Marques Dos Santos, Caixia Li, Shane A. Snyder

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


The ubiquitous presence of per- and polyfluoroalkyl substances (PFAS) in various environments has led to increasing concern, and these chemicals have been confirmed as global contaminants. Following the chemical regulatory restrictions imposed, PFAS alternatives that are presumed to be less toxic have been manufactured to replace the traditional ones in the market. However, owing to the original release and alternative usage, continuous accumulation of PFAS has been reported in environmental and human samples, with uncertain consequences for ecosystem and human health. It is crucial to promote and improve existing analytical techniques to facilitate the detection of trace amounts of PFAS in diverse environmental matrices. This review summarizes analytical methods that have been applied to and advanced for targeted detection and suspect screening of PFAS, which mainly include (i) sampling and sample preparation methods for various environment matrices and organisms, and quality assurance/quality control during the analysis process, and (ii) quantitative methods for targeted analysis and automated suspect screening strategies for non-targeted PFAS analysis, together with their applications, advantages, shortcomings, and need for new method development.

Original languageEnglish (US)
Pages (from-to)2795-2807
Number of pages13
JournalAnalytical and bioanalytical chemistry
Issue number9
StatePublished - Apr 2022
Externally publishedYes


  • Analytical method development
  • Non-targeted discovery
  • Per- and polyfluoroalkyl substances (PFAS)
  • Targeted analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


Dive into the research topics of 'Recent advances in mass spectrometry analytical techniques for per- and polyfluoroalkyl substances (PFAS)'. Together they form a unique fingerprint.

Cite this