Recent advances in our understanding of the biochemical interactions between platelet-activating factor and arachidonic acid

Floyd H. Chilton, Marc Cluzel, Massimo Triggiani

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

In the last few years, it has become increasingly apparent that the biochemistry of PAF (platelet-activating factor) and that of arachidonic acid are interrelated in a number of inflammatory cells. Experiments presented here further point out that arachidonic acid plays a crucial role in the catabolism and biosynthesis of PAF. In addition, they suggest that the same phospholipid molecular species may serve as a source for both arachidonic acid and 1-alkyl-2-lyso-sn-glycero-3-phosphocholine during cell activation. Finally, they reveal that there may be common regulatory mechanisms for the biosynthesis of PAF and arachidonic acid metabolites. Taken together, studies examining the relationship between PAF and arachidonic acid suggest it may be difficult to consider the biochemistry of PAF without considering arachidonic acid metabolism and vice versa.

Original languageEnglish (US)
Pages (from-to)1021-1027
Number of pages7
JournalLipids
Volume26
Issue number12
DOIs
StatePublished - Dec 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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