Recent advances in haploidentical hematopoietic cell transplantation for pediatric hematologic malignancies

Kristie N. Ramos, Emmanuel Katsanis

Research output: Chapter in Book/Report/Conference proceedingChapter


Haploidentical hematopoietic cell transplant (h-HCT) has become the most frequently applied alternate HCT approach. An obvious benefit of h-HCT is that it offers a potential readily available family donor to almost every patient. The application of h-HCT has particularly benefited minority populations who frequently do not find a suitable unrelated donor. Different options exist utilizing either T cell depletion strategies or T cell-replete grafts with myeloablative or reduced intensity conditioning. Graft failures are generally low (<5%) in recent pediatric series with myeloablative regimens. Grade III-IV acute graft-versus-host disease (GvHD) and chronic GvHD have ranged between 7-20% and 5-33%. Patients in remission and those that receive MAC regimens have lower rates of relapse with outcomes comparable to those of matched unrelated transplants and in some studies matched sibling transplants. Research is still needed to determine the optimal donor and graft characteristics, GvHD prophylaxis, and to improve immune reconstitution and control post-HCT infections.

Original languageEnglish (US)
Title of host publicationCancer Immunology
Subtitle of host publicationBench to Bedside Immunotherapy of Cancers, Second Edition
PublisherSpringer International Publishing
Number of pages12
ISBN (Electronic)9783030502874
ISBN (Print)9783030502867
StatePublished - Sep 24 2020


  • Haploidentical hematopoietic cell transplant
  • Post-transplant cyclophosphamide
  • T cell depletion
  • T cell replete
  • TCR-alphabeta+/CD19+ lymphocyte depletion

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


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