TY - GEN
T1 - Real-time thermoacoustic imaging and thermometry in bovine udder tissue comparing two calibration methods
AU - Tamimi, Ehab A.
AU - Xin, Hao
AU - Witte, Russell S.
N1 - Funding Information:
This work was funded by the U.S. Department of Defense CDMRP Grant # W81XWH-16-1-0423, W81XWH-16-1-0424. RSW has a financial interest in ElectroSonix LLC, which did not contribute to this study. The authors declare no other conflicts of interest.
Publisher Copyright:
© 2020 IEEE.
PY - 2020/9/7
Y1 - 2020/9/7
N2 - Thermoacoustic (TA) thermometry requires calibration to establish the relationship between the change in TA signal with the change in temperature. Previous studies have used a priori slopes values (i.e. TA signal vs temperature), typically determined experimentally from previously performed standard calibrations. However, standard calibration requires more than one test and is not robust to changing sample orientation or composition. The goal of this study is to compare a previously studied self-calibration method to the standard calibration method in estimating temperature using real-time 3D TA thermometry in bovine udder tissue kept in the same orientation for both methods. The self-calibration and standard methods estimated temperatures of the udder sample during localized heating with a normalized root mean square errors (NRMSE) of 7.1% and 8.4%, respectively. The predicted temperatures produced by the self-calibration method were less variable than the standard method. Overall, the qualitative and quantitative results comparing predicted change in temperature suggested that self-calibration is as accurate as standard calibration with less variability and less experimentation. These advantages point to self-calibration being a more preferred method to provide temperature predictions for feedback control in future breast cancer ablation therapy.
AB - Thermoacoustic (TA) thermometry requires calibration to establish the relationship between the change in TA signal with the change in temperature. Previous studies have used a priori slopes values (i.e. TA signal vs temperature), typically determined experimentally from previously performed standard calibrations. However, standard calibration requires more than one test and is not robust to changing sample orientation or composition. The goal of this study is to compare a previously studied self-calibration method to the standard calibration method in estimating temperature using real-time 3D TA thermometry in bovine udder tissue kept in the same orientation for both methods. The self-calibration and standard methods estimated temperatures of the udder sample during localized heating with a normalized root mean square errors (NRMSE) of 7.1% and 8.4%, respectively. The predicted temperatures produced by the self-calibration method were less variable than the standard method. Overall, the qualitative and quantitative results comparing predicted change in temperature suggested that self-calibration is as accurate as standard calibration with less variability and less experimentation. These advantages point to self-calibration being a more preferred method to provide temperature predictions for feedback control in future breast cancer ablation therapy.
KW - Thermoacoustic imaging
KW - Thermometry
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85097908287&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097908287&partnerID=8YFLogxK
U2 - 10.1109/IUS46767.2020.9251351
DO - 10.1109/IUS46767.2020.9251351
M3 - Conference contribution
AN - SCOPUS:85097908287
T3 - IEEE International Ultrasonics Symposium, IUS
BT - IUS 2020 - International Ultrasonics Symposium, Proceedings
PB - IEEE Computer Society
T2 - 2020 IEEE International Ultrasonics Symposium, IUS 2020
Y2 - 7 September 2020 through 11 September 2020
ER -