Reactivity of biarylazacyclooctynones in copper-free click chemistry

Medicine & Life Sciences

• Alkynes 67%
• Azides 87%
• Click Chemistry 100%
• Copper 62%
• Cycloaddition Reaction 68%
• Density Functional Theory 35%
• Kinetics 14%
• Lactams 29%
• X Ray Crystallography 28%

Engineering & Materials Science

• Conformations 26%
• Copper 50%
• Cycloaddition 83%
• Density functional theory 30%
• Electronic equipment 17%
• Lactams 38%
• Rate constants 25%
• Reaction rates 23%
• Reagents 24%
• X ray crystallography 35%

Chemical Compounds

• 1,3-cycloaddition 10%
• Alkyne 17%
• Application 3%
• Azide 28%
• Cycloaddition 8%
• Cyclooctyne 97%
• Density Functional Theory 6%
• Dihedral Angle 26%
• Energy 9%
• Lactam 11%
• Process Dynamics 12%
• Rate Constant 6%
• Steric Effect 10%
• Steric Hindrance 9%
• Strain 7%
• Transition State 25%
• X-Ray Crystallography 8%