TY - JOUR
T1 - Reactivation of hippocampal ensemble activity patterns in the aging rat
AU - Gerrard, Jason L.
AU - Kudrimoti, Hemant
AU - McNaughton, Bruce L.
AU - Barnes, Carol A.
PY - 2001
Y1 - 2001
N2 - In young rats, the pattern of neuronal ensemble activity correlations expressed among hippocampal pyramidal cells during behavior persists during subsequent quiet wakefulness and slow-wave sleep, a process that may facilitate the consolidation of episodic memories. The present study explored the hypothesis that age-related changes in this process might contribute to memory impairments observed during normal aging. Neuronal activity was recorded from CA1 pyramidal cells, and in both young and old rats, there was a strong similarity between the resting epoch activity patterns and those from the preceding behavior epoch. This similarity was strongest during sharp-wave events. There were no detectable differences in the reactivation process or the decay rate between the young and old age groups. Thus, age differences in spatial memory do not appear to be explainable by differences in the spontaneous reactivation of familiar patterns within the hippocampus during the immediate postbehavior period.
AB - In young rats, the pattern of neuronal ensemble activity correlations expressed among hippocampal pyramidal cells during behavior persists during subsequent quiet wakefulness and slow-wave sleep, a process that may facilitate the consolidation of episodic memories. The present study explored the hypothesis that age-related changes in this process might contribute to memory impairments observed during normal aging. Neuronal activity was recorded from CA1 pyramidal cells, and in both young and old rats, there was a strong similarity between the resting epoch activity patterns and those from the preceding behavior epoch. This similarity was strongest during sharp-wave events. There were no detectable differences in the reactivation process or the decay rate between the young and old age groups. Thus, age differences in spatial memory do not appear to be explainable by differences in the spontaneous reactivation of familiar patterns within the hippocampus during the immediate postbehavior period.
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U2 - 10.1037/0735-7044.115.6.1180
DO - 10.1037/0735-7044.115.6.1180
M3 - Article
C2 - 11770050
AN - SCOPUS:0035211725
SN - 0735-7044
VL - 115
SP - 1180
EP - 1192
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 6
ER -