Reaction of the antitumor antibiotic CC-1065 with DNA: Structure of a DNA adduct with DNA sequence specificity

Laurence H. Hurley; Vincent L. Reynolds; David H. Swenson; Gary L. Petzold; Terry A. Scahill

doi:10.1126/science.6494915

Reaction of the antitumor antibiotic CC-1065 with DNA: Structure of a DNA adduct with DNA sequence specificity

Laurence H. Hurley, Vincent L. Reynolds, David H. Swenson, Gary L. Petzold, Terry A. Scahill

Research output: Contribution to journal › Article › peer-review

275 Scopus citations

Abstract

Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.

Original language	English (US)
Pages (from-to)	843-844
Number of pages	2
Journal	Science
Volume	226
Issue number	4676
DOIs	https://doi.org/10.1126/science.6494915
State	Published - 1984
Externally published	Yes

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abstract = "Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.",

author = "Hurley, {Laurence H.} and Reynolds, {Vincent L.} and Swenson, {David H.} and Petzold, {Gary L.} and Scahill, {Terry A.}",

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T1 - Reaction of the antitumor antibiotic CC-1065 with DNA

T2 - Structure of a DNA adduct with DNA sequence specificity

AU - Hurley, Laurence H.

AU - Reynolds, Vincent L.

AU - Swenson, David H.

AU - Petzold, Gary L.

AU - Scahill, Terry A.

PY - 1984

Y1 - 1984

N2 - Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.

AB - Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.

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Reaction of the antitumor antibiotic CC-1065 with DNA: Structure of a DNA adduct with DNA sequence specificity

Abstract

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